The Lord does not give up on people. He knows who is His and will not leave one behind. You must not give up co-laboring for the souls of those that the Lord has placed on your heart no matter the circumstances or your personal tiredness. Salvation is coming!
2 Corinthians 6: (AMP)
1 LABORING TOGETHER [as God’s fellow workers] with Him then, we beg of you not to receive the grace of God in vain [that [a]merciful kindness by which God exerts His holy influence on souls and turns them to Christ, keeping and strengthening them–do not receive it to no purpose].
2 For He says, In the time of favor (of an assured welcome) I have listened to and heeded your call, and I have helped you on the day of deliverance (the day of salvation). Behold, now is truly the time for a gracious welcome and acceptance [of you from God]; behold, now is the day of salvation!